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| Wesley Snipes | Blade | |
| Kris Kristofferson | Whistler | |
| Danny John-Jules | Asad | |
| Thomas Kretschmann | Overlord Eli Damaskinos | |
| Luke Goss | Jared Nomak | |
| Ron Perlman | Dieter Reinhardt | |
| Norman Reedus | Josh Frohmeyer | |
| Matt Schulze | Chupa | |
| Leonor Varela | Nyssa Damaskinos | |
| Karel Roden | Carter Kounen | |
| Marit Velle Kile | Verlaine |
| Director |
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| Producer | Peter Frankfurt
Wesley Snipes |
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| Writer | David S. Goyer
Marv Wolfman |
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| Cinematography | Gabriel Beristain
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| Musician | Marco Beltrami
Danny Saber |
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A rare mutation has occurred within the vampire community - The Reaper. A vampire so consumed with an insatiable bloodlust that they prey on vampires as well as humans, transforming victims who are unlucky enough to survive into Reapers themselves. Blade is asked by the Vampire Nation for his help in preventing a nightmare plague that would wipe out both humans and vampires. |
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