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| John Candy | Buck Russell | |
| Macaulay Culkin | Miles Russell | |
| Amy Madigan | Chanice Kobolowski | |
| Jean Louisa Kelly | Tia Russell | |
| Gaby Hoffmann | Maizy Russell | |
| Elaine Bromka | Cindy Russell | |
| Garrett M. Brown | Bob Russell | |
| Laurie Metcalf | Marcie Dahlgren-Frost | |
| Brian Tarantina | E. Roger Coswell |
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| Producer | John Hughes
Bill Brown |
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| Writer | John Hughes
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Uncle Buck has a reputation for being unreliable and a bit of a house wrecker. It is therefore with reluctance, his sister-in-law agrees to leave Buck looking after the kids (two harmless youngsters and a rebelious teenager) when she visits her sick father. |
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